Технология mRNA-дисплея ускоряет поиск новых пептидных лекарств с аффинностью антител

mRNA Display: Revolutionizing Drug Discovery The poster highlights its mRNA display as a powerful in vitro selection platform featuring ultra-high-diversity peptide libraries (up to 10^15) that rapidly discovers novel macrocyclic peptide binders with antibody-like affinities across diverse therapeutic targets, achieving binding strengths from high nanomolar to picomolar levels. Download Ready Click below to begin your download. mRNA display is a powerful in vitro selection and directed evolution technique for discovering novel (macrocyclic) peptide binders with antibody-like affinities and even potential oral bioavailability. Our mRNA display platform features diverse libraries (linear, monocyclic, and bicyclic peptides) with ultra-high-diversity (up to 10^15), enabling rapid screening against nearly any biological target. Additionally, by incorporating unnatural amino acids into macrocyclic peptide libraries, our platform can generate peptide hits with enhanced physicochemical properties and optimized pharmacokinetics. Our poster highlights the broad applicability of the platform across diverse therapeutic modalities. We will showcase how the platform can be effectively applied across diverse target classes through several case studies demonstrating its robust performance and ability to generate peptide binders with affinities ranging from high nanomolar (three-digit nM) to picomolar (pM) levels. TIDES USA Apr 26, 2027 TO Apr 29, 2027 |Boston, MA North America's premier event for accelerating oligonucleotide and peptide innovations through collaborative discovery, development, and commercialization. where industry pioneers explore cutting-edge strategies across oligos, peptides, mRNA, and genome editing to transform therapeutics from discovery to market reality.