В Мадураи успешно проведена почечная трансплантация при несовместимости групп крови с помощью иммуоадсорбции

Apollo Speciality Hospitals in Madurai has performed an ABO-incompatible living-donor kidney transplantation using advanced antigen-specific immunoadsorption therapy. According to a press release, the procedure enabled a 40-year-old man with blood group O positive to receive a kidney from his wife, who had blood group A positive. Consultant Nephrologist P. Arun Prasath said ABO-incompatible transplantation requires meticulous immunological preparation, particularly when the recipient has a high antibody titre. ABO-incompatible recipients have naturally occurring antibodies against the donor’s blood-group antigens, which, if present at high levels, can attack the transplanted kidney and lead to antibody-mediated rejection and compromised graft function. Therefore, desensitisation to reduce these antibodies to an acceptable level is a critical part of transplantation across an ABO barrier. In this case, antigen-specific immunoadsorption provided a targeted approach by selectively removing anti-A antibodies while returning the treated plasma to the patient. The patient’s anti-A antibody titre was successfully reduced from 1:256 to 1:8, enabling us to proceed safely with transplantation, he said. The successful outcome demonstrates the importance of personalised desensitisation strategies, careful monitoring of antibody titres, and close assessment of the patient’s overall clinical condition, particularly in a case where conventional plasma exchange presented challenges. Immunoadsorption can offer a targeted method of antibody removal in appropriately selected patients undergoing ABO-incompatible transplantation, he said. Published - September 04, 2026 12:06 am IST